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In Vivo Kinetics and Biotransformation of Aflatoxin B1 in Dairy Cows Based on the Establishment of a Reliable UHPLC-MS/MS MethodDataSheet1.docx

in Chemistry, Volume 9 (2021) Keywords: Aflatoxins biotransformation dairy cow in vivo kinetics UHPLC-MS/MS Abstract: The in vivo kinetics of aflatoxin B1  (AFB1) and its carry-over as aflatoxin M1 ...

Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens

chickens (Vd = 2.46 L/kg after IV administration). However, plasma protein binding did not differ statistically significant (91-98%). It is imperative to further investigate biotransformation and elimination ...

Insights into In Vivo Absolute Oral Bioavailability, Biotransformation, and Toxicokinetics of Zearalenone, α-Zearalenol, β-Zearalenol, Zearalenone-14-glucoside, and Zearalenone-14-sulfate in Pigs

Publication Type: Peer reviewed scientific article Authors: Catteuw, Amelie; Broekaert, Nathan; De Baere, Siegrid; Lauwers, Marianne; Gasthuys, Elke; B Huybrechts; A. Callebaut; Ivanova, Lada; Uhlig, Silvio; De Boevre, Marthe; S. De Saeger; Gehring, Ronet ...

CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation.

genetic polymorphisms in a biotransformation enzyme (CYP3A5) and a transporter protein (ABCB1) on tacrolimus (Tac) whole blood concentrations in renal transplantation, and more specifically on peripheral ...

1199G> A and 2677G> T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation.

biotransformation enzymes or transporter proteins, such as CYP3A5 and P-glycoprotein (ABCB1), in donors and/or recipients, appear as important determinants of the Tac blood pharmacokinetics. A recent study has shown ...

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