Zoekresultaten - 171 results

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review.

while CVD incidence rises steadily with the aging population. Although numerous experimental studies are now available, the mechanisms through which lifetime exposure to environmental pollutants can ...

Applicability of the DPRA on mixture testing: challenges and opportunities.

limited experimental data are publicly available. First, we assessed the DPRA ’s predictive capability for individual substances, but at concentrations other than the recommended 100 mM, i.e., based on the ...

Lumpy Skin Disease: A Systematic Review of Mode of Transmission, Risk of Emergence and Risk Entry Pathway.

literature including scientific journals, books, and conference proceedings). A total of 86 scientific articles were considered and classified according to the type of epidemiological study, i.e., experimental ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.

towards a more human-relevant in vitro genotoxicity testing strategy without the use of experimental animals. Health Topics:  Health and environment Santé et environnement Gezondheid en milieu Service:  ...

Predicting the severity of the grass pollen season and the effect of climate change in Northwest Europe

suggest annual severity is largely governed by preseasonal meteorological conditions. The mechanistic model suggests climate change will increase the season severity by up to 60%, in line with experimental ...

Targeted High-Throughput Sequencing Enables the Detection of Single Nucleotide Variations in CRISPR/Cas9 Gene-Edited Organisms

experimental-based evidence indicating that the proposed targeted high-throughput sequencing approach may constitute, in the future, a specific and sensitive tool to support the safety and traceability of the ...

Offering HPV self-sampling kits: an updated meta-analysis of the effectiveness of strategies to increase participation in cervical cancer screening

testing compared to conventional invitations and to compare different self-sampling invitation scenarios. Four experimental invitational scenarios were considered. Women in the control group were invited ...

Impact of experimental design factors on the potency of genotoxicants in in vitro test

Abstract: Previous studies have shown that differences in experimental design factors may alter the potency of genotoxic compounds in in vitro genotoxicity tests. Most of these studies used traditional ...

Humoral and cellular immune responses against SARS-CoV-2 after third dose BNT162b2 following double-dose vaccination with BNT162b2 versus ChAdOx1 in cancer patients.

study compares a third dose of BNT162 b2 after double-dose BNT162 b2 (homologous) versus ChAdOx1 (heterologous) vaccination in cancer patients. EXPERIMENTAL DESIGN: 442 subjects (315 patients and 127 ...

Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells

genetic toxicology GENOMARK biomarker predictive toxicology human health risk assessment new approach methodologies (NAMs) Abstract: Transcriptomics-based biomarkers are promising new approach methodologies ...

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