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Zoekresultaten - 165 results
The GEN-ERA toolbox: unified and reproducible workflows for research in microbial genomics
contamination estimation, to tree reconstruction. It also offers workflows for average nucleotide identity comparisons and metabolic modeling. Technical details: Nextflow workflows are launched by a single ...
Discovery and Development of an Advanced Lead for the Treatment of African Trypanosomiasis.
identified following screening against the most relevant trypanosome species. Selected hit compounds were extensively tested for metabolic stability, potency in mouse models for the various species, ...
Metabolic health in people living with type 1 diabetes in Belgium: a repeated cross-sectional study
Publication Type: Peer reviewed scientific article Authors: Astrid Lavens; De Block, Christophe; Oriot, Philippe; Crenier, Laurent; Philips, Jean-Christophe; Vandenbroucke, Michel; Vanherwegen, An-Sofie; Nobels, Frank; Mathieu, Chantal; on behalf of the I ...
Assessment of receptor-mediated activity (AhR and ERα), mutagenicity, and teratogenicity of metal shredder wastes in Wallonia, Belgium.
S9 metabolic fraction) whereas in the TA100 strain (+ S9 metabolic fraction), only the sludge sample (site 2) showed a clear mutagenic effect. The in vivo toxicity/teratogenicity of the shredder ...
Experimental accumulation and depuration kinetics and natural occurrence of microcystin-LR in basil (Ocimum basilicum L.).
treatment conditions. For MC- LR depuration, significant reductions were observed in all the treatment conditions for roots only. No MC- LR conjugates, potentially related to metabolism, were detected by LC- ...
Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals.
classification accuracy for genotoxicity. As these biomarkers were extracted from different training sets, we investigated whether combining the two biomarkers in a human-derived metabolically competent cell line ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.
DNA microarray profiles of 24 (non-)genotoxic reference chemicals covering different modes of action in metabolically competent human HepaRG™ cells. In the present study, new prediction models for ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells
microarray profiles of 24 (non-)genotoxic reference chemicals covering different modes of action in metabolically competent human HepaRG™ cells. In the present study, new prediction models for genotoxicity ...
Development, Validation and Application of a Targeted LC-MS Method for Quantification of Microcystins and Nodularin: Towards a Better Characterization of Drinking Water
(PPIIA), disrupting cell growth and metabolism [15,16]. When ingested, these toxins are transported by the bile salts to the liver, potentially causing liver damage [17,18,19]. Health Topics: Food ...
Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial
Ampe; Vangoitsenhoven, Roman; Ann Mertens; Rudi Vennekens; Van der Schueren, Bart Source: European Journal of Drug Metabolism and Pharmacokinetics, Volume 47, Issue 6 (2022) Abstract: Background ...