Homologous versus heterologous prime-boost COVID-19 vaccination: impact on clinical severity of Omicron among hospitalized COVID-19 patients in Belgium

Last updated on 11-1-2024 by Joris Van Loenhout

Scientific poster, presentation or proceeding





Background We investigated the real-world effectiveness of a heterologous versus homologous primeboost vaccination scheme against severe clinical outcomes of SARS-CoV-2 Omicron infection among hospitalized patients in Belgium, and if this effect is homogenous across different Omicron sub-lineages. Methods Observational data from existing national surveillance systems and administrative sources were leveraged to estimate a causal effect. A Directed Acyclic Graph was formalized to identify confounding factors. The target population consisted of adult COVID-19 patients admitted to a B…

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